Key Facts
- Machine learning advances in drug toxicity prediction could enhance safety in clinical trials.

- Validation using data from 434 hazardous drugs and 790 approved drugs revealed significant associations with drug failure due to toxicity.

- The developed AI model shows superior predictive performance compared to existing state-of-the-art models.

- This represents the first attempt to include differences in genotype-phenotype relationships in toxicity predictions.

- Dr. Min-hyuk Park stated that the human-centered toxicity prediction model will be a very practical tool in new drug development.

- The framework aims for early identification of high-risk drugs during clinical development.
- The model's effectiveness is projected to improve as more data becomes available.

A machine-learning-based technology has been developed to learn these differences and preemptively identify potentially dangerous drugs before clinical trials.
News-Medical